Cradle vs EvolutionaryScale

A side-by-side comparison of Cradle and EvolutionaryScale, two Science tools, drawn from Ignaite's continuously-verified listings.

Compared from listings verified as of 2026-06-14

Cradle

Science

AI protein-engineering platform for faster lab design rounds.

View Cradle

EvolutionaryScale

Science

Frontier protein language models (the ESM family) for biology.

View EvolutionaryScale

At a glance

Feature comparison of Cradle and EvolutionaryScale
Attribute	Cradle	EvolutionaryScale
Category	Science	Science
Pricing (differs)	PAID	FREEMIUM
License (differs)	Proprietary	Open core
Deployment	Cloud	Cloud
Platforms (differs)	Web	API, Web
Model support	—	—
Vendor (differs)	Cradle	EvolutionaryScale

The honest brief

Cradle

Self-serve web SaaS for protein engineering with per-customer models and an in-house wet lab — a usable product where most rivals are partnership-only.

Self-serve web platform
Multi-property optimization
Per-customer models on your lab data
Customers keep IP, no royalties

Enterprise sales-led pricing
No public free tier
Needs customer wet-lab data
Not a downloadable model

EvolutionaryScale

The team behind Meta's original ESM models, now shipping open ESM3 weights plus a hosted Forge API — research-grade openness with commercial serving.

Open ESM3 weights
Reasons over sequence/structure/function
Served via AWS and NVIDIA partnerships
Ex-Meta ESM team

Open weights non-commercial only
Forge in closed beta
Largest models gated
Pricing undisclosed

Cradle details EvolutionaryScale details All Science apps