EvolutionaryScale

Foundation models for molecular structure and antibody design.

Chai Discovery builds foundation models for drug discovery — Chai-1 for biomolecular structure prediction across proteins, ligands, DNA/RNA, and glycans, and Chai-2 for de novo antibody design. Chai-1 weights and inference code are released for non-commercial use, and a free web server runs the model in-browser. It is both a model provider and a usable platform.

Generative protein language models that design novel proteins.

Profluent uses generative AI — its ProGen-lineage protein language models — to author novel proteins from scratch or from natural scaffolds, for medicine and agriculture. It released OpenCRISPR-1, described as the first AI-designed gene editor (open-licensed and published in Nature), and is expanding into antibodies and enzymes. It operates as an AI protein-design company working through partnerships with open-sequence releases, not a self-serve consumer platform.

AI protein-engineering platform for faster lab design rounds.

Cradle is an AI-powered protein-engineering SaaS platform that guides scientists through design rounds — candidate generation, multi-property optimization, and results analysis — using ML models trained per-customer on proprietary wet-lab data. It runs its own validation wet lab in Amsterdam and serves biopharma and industrial-biotech R&D teams including Novo Nordisk and Johnson & Johnson. It is sold via subscription with no royalties, and customers keep full IP.