Profluent

AI protein-engineering platform for faster lab design rounds.

Cradle is an AI-powered protein-engineering SaaS platform that guides scientists through design rounds — candidate generation, multi-property optimization, and results analysis — using ML models trained per-customer on proprietary wet-lab data. It runs its own validation wet lab in Amsterdam and serves biopharma and industrial-biotech R&D teams including Novo Nordisk and Johnson & Johnson. It is sold via subscription with no royalties, and customers keep full IP.

Frontier protein language models (the ESM family) for biology.

EvolutionaryScale builds frontier protein language models — the ESM family, including ESM3, which reasons jointly over sequence, structure, and function. ESM3-open ships open weights and code under a non-commercial license, while larger models are served via its Forge API and AWS/NVIDIA partnerships. It is both an open-model provider and an API platform for protein design and understanding.

Foundation models for molecular structure and antibody design.

Chai Discovery builds foundation models for drug discovery — Chai-1 for biomolecular structure prediction across proteins, ligands, DNA/RNA, and glycans, and Chai-2 for de novo antibody design. Chai-1 weights and inference code are released for non-commercial use, and a free web server runs the model in-browser. It is both a model provider and a usable platform.