Isomorphic Labs

Foundation models for molecular structure and antibody design.

Chai Discovery builds foundation models for drug discovery — Chai-1 for biomolecular structure prediction across proteins, ligands, DNA/RNA, and glycans, and Chai-2 for de novo antibody design. Chai-1 weights and inference code are released for non-commercial use, and a free web server runs the model in-browser. It is both a model provider and a usable platform.

Generative protein language models that design novel proteins.

Profluent uses generative AI — its ProGen-lineage protein language models — to author novel proteins from scratch or from natural scaffolds, for medicine and agriculture. It released OpenCRISPR-1, described as the first AI-designed gene editor (open-licensed and published in Nature), and is expanding into antibodies and enzymes. It operates as an AI protein-design company working through partnerships with open-sequence releases, not a self-serve consumer platform.

Autonomous AI labs pursuing scientific superintelligence.

Lila Sciences is building a 'scientific superintelligence' platform that pairs a proprietary AI model with autonomous AI Science Factory lab instruments to generate hypotheses, design and run experiments, and learn in real time. It offers Catalyst, which augments existing R&D, and Creation, for new discoveries, across materials, therapeutics, chemicals, and energy. It is a platform and research company engaged through partnership rather than self-serve.