Microsoft Agent Framework

Graph-based agent orchestration. Stateful loops with checkpoints.

LangChain's agent layer. Model agents as nodes in a state graph with persistent checkpoints, human-in-the-loop steps, and durable execution. Strong when you need a long-running, debuggable agent rather than a one-shot chain.

Multi-agent framework with explicit roles and tasks.

Python framework for orchestrating crews of specialised agents — researcher, writer, reviewer — coordinated through shared context. Opinionated about roles, sequencing, and delegation; good fit for content-and-research pipelines.

Type-safe Python agent framework, the Pydantic way.

An open-source Python framework for building production-grade agents with validated, structured outputs instead of raw-string parsing. Model-agnostic across OpenAI, Anthropic, Gemini and many more, with composable tools, durable execution, MCP support, and built-in observability via Pydantic Logfire. MIT-licensed from the team behind Pydantic.

High-performance Python framework for multi-agent systems.

Agno is an open-source Python framework for building multi-agent systems with memory, knowledge, tools, and reasoning. Agents are fast to instantiate and can be composed into teams, and the companion AgentOS runtime serves them in production as a FastAPI app with a control plane.